Differential gene expression in ADAM10 over-expressing transgenic mice

In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the -secretase ADAM10 prevented amyloid plaque formation and alleviated cognitive deficits. Furthermore, there was a positive influence of ADAM10 over-expression on neurotransmitter-specific formation of synapses and on synaptic plasticity.

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Prinzen C, Trümbach D, Wurst W, Endres K, Postina R, Fahrenholz F