Effect of an anti-myostatin antibody on skeletal muscle gene expression in mice

GSE13707

Mus musculus

20 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

More than 2,000 genes appear to be upregulated or downregulated in skeletal muscle of mice with constitutive knockout of myostatin (Steelman et al., FASEB J 20:580-2, 2006). This study was done to determine whether inhibition of myostatin activity in mature mice has similar effects on the pattern of gene expression.

PubMed ID

19141683

Publication Title

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice.

Total Samples

Submitter’s Institution

University of Rochester

Authors

Welle S, Burgess K, Mehta S

Source Repository

Gene Expression Omnibus (GEO)

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