Effects of acute Notch activation on the mammary epithelial compartment in vivo

GSE51628

Mus musculus

15 Downloadable Samples

Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description

Notch signaling is widely implicated in mouse mammary gland development and tumorigenesis. To investigate the effects of acute activation of Notch signaling in the mammary epithelial compartment, we generated bi-transgenic MMTV-rtTA; TetO-NICD1 (MTB/TICNX) mice that conditionally express a constitutively active NOTCH1 intracellular domain (NICD1) construct in the mammary epithelium upon doxycycline administration.

PubMed ID

25961456

Publication Title

Notch promotes recurrence of dormant tumor cells following HER2/neu-targeted therapy.

Total Samples

Submitter’s Institution

University of Pennsylvania

Authors

Abravanel DL, Belka GK, Pan TC, Pant DK, Collins MA, Sterner CJ, Chodosh LA

Source Repository

Gene Expression Omnibus (GEO)

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