Effects of APP Antisense Treatment on Hippocampal Gene Expression in Adult Mice with Memory Deficits

The purpose of this study was to determine the effect of peripheral (IV) administration of APP antisense on hippocampal gene expression as well as on learning and memory as measured by T-maze in adult male mice aged 12 months. The APP antisense treatment reversed learning and memory deficits and altered the expression of 944 hippocampal genes, which are involved in a coordinated set of signaling pathways. Expression and pathway findings were verified at the protein and functional (phosphorylation) levels.

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