Transcriptional profiling through RNA-seq of zebrafish larval liver after exposure to biliatresone, a biliary toxin.

SRP068364

Danio rerio

4 Downloadable Samples

Illumina HiSeq 2000

Submitter Supplied Information

Description

We sequenced liver mRNA isolated from biliatresone-treated zebrafish larvae and DMSO-treated controls in order to elucidate the molecular pathways induced by biliatresone, a biliary toxin that is responsible for outbreaks of biliary atresia in Australian liverstock. Overall design: Liver mRNA profiles of biliatresone-treated zebrafish larvae and DMSO-treated controls were generated by deep sequencing, in duplicates.

PubMed ID

27102575

Publication Title

Glutathione antioxidant pathway activity and reserve determine toxicity and specificity of the biliary toxin biliatresone in zebrafish.

Total Samples

Submitter’s Institution

No associated institution

Authors

Zhao X, Lorent K, Wilkins BJ, Marchione DM, Gillespie K, Waisbourd-Zinman O, So J, Koo KA, Shin D, Porter JR, Wells RG, Blair I, Pack M

Source Repository

Sequence Read Archive (SRA)

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