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accession-icon SRP075685
Genome-wide maps of histone variant H3.3 occupancy in zebrafish cardiomyocytes [RNA]
  • organism-icon Danio rerio
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIlluminaHiSeq4000

Description

We report high-throughput profiling of gene expression from whole zebrafish ventricles. We profile mRNA in uninjured ventricles and those undergoing regeneration 14 days after genetic ablation. This study provides a framework for understanding transcriptional changes during adult models of regeneration. Overall design: Examination of gene expression in cardiomyocytes under different states of proliferation.

Publication Title

Resolving Heart Regeneration by Replacement Histone Profiling.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE30457
Dissecting primary (translation independent) from secondary (translation dependent) IFN-mediated differential gene expression
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon

Description

NIH-3T3 cells were pretreated for 15 min with either DMSO (mock) or cycloheximide followed by addition of either mock, 100 U/ml IFNalpha or 100 U/ml IFNgamma for 1h. During the last 30 min, 500 M 4-thiouridine was added to cell culture medium. Total cellular RNA was isolated using Trizol reagent and nascent RNA was purified as described (Dlken et al. RNA 2008) . Three replicates of nascent RNA were analyzed by Affymetrix Mouse Gene ST 1.0 arrays

Publication Title

Deciphering the modulation of gene expression by type I and II interferons combining 4sU-tagging, translational arrest and in silico promoter analysis.

Sample Metadata Fields

Cell line

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accession-icon GSE51250
Combined targeting of JAK2 and Bcl-xL/Bcl-2 as a novel curative treatment for malignancies expressing mutant JAK2 and overcoming acquired resistance to single agent JAK2 inhibitors
  • organism-icon Mus musculus
  • sample-icon 9 Downloadable Samples
  • Technology Badge Icon

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Combined targeting of JAK2 and Bcl-2/Bcl-xL to cure mutant JAK2-driven malignancies and overcome acquired resistance to JAK2 inhibitors.

Sample Metadata Fields

Specimen part, Disease, Disease stage

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