T cell development relies on the precise developmental control of various cellular functions for appropriate positive and negative selection. Previously, gene expression profiling of peptide-driven negative selection events in the N15 TCR class I MHC-restricted mouse and D011.10 TCR class II MHC-restricted mouse has offered insights into the coordinate engagement of biological processes affecting thymocyte development. However, there has been little comparable detailed in vivo global genome expression analysis reported for positive selection.
PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla.
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View SamplesGene expressions of murine germinal center and naive B cells on Affymetrix platform
Multiple transcription factor binding sites predict AID targeting in non-Ig genes.
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