Description

Inhibition of miR-33 results in increased cholesterol efflux and HDL-cholesterol levels in mice. In this study we examined the effect of miR-33 inhibition in a mouse model of atherosclerosis and observed significant reduction in atherosclerotic plaque size. At the end of the study, gene expression in macrophages from the atherosclerotic plaques was assessed.

Publication Title

Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis.

Sample Metadata Fields

Sex, Specimen part