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accession-icon GSE26809
FMRP Associates with Polyribosomes
  • organism-icon Mus musculus
  • sample-icon 26 Downloadable Samples
  • Technology Badge Icon

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Sample Metadata Fields

Sex, Specimen part

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accession-icon GSE26745
Comparison of total and polyribosome-associated mRNA levels in male Fmr1 KO mice and male WT littermates
  • organism-icon Mus musculus
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon

Description

The Fragile X Mental Retardation Protein, FMRP, is thought to regulate the translation of a specific set of neuronal mRNAs on polyribosomes. Therefore, we prepared polyribosomes on sucrose gradients and purified mRNA specifically from these fractions, as well as the total mRNA levels, to determine whether a set of mRNAs might be changed in its % association with polyribosomes in the absence of FMRP in the KO mouse model.

Publication Title

FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism.

Sample Metadata Fields

Sex, Specimen part

View Samples
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