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accession-icon GSE38850
Expression profiling of mouse embryonic stem cells (ESCs) (cell line V6.5, 129SvJae/C57B6 F1 background), and mouse ESC-derived Neural Precursor Cells (NPCs)
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
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Description

ESCs and NPCs are two setm cell types which rely on expression of the transcription factor Sox2. We profilled gene expression in ESCs and NPCs to correlate genome-wide Sox2 ChIP-Seq data in these cells with expression of putative targets

Publication Title

SOX2 co-occupies distal enhancer elements with distinct POU factors in ESCs and NPCs to specify cell state.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE39388
Distinct transcriptional programs controlled by ERG and ETV1 in prostate cells
  • organism-icon Mus musculus, Homo sapiens
  • sample-icon 41 Downloadable Samples
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Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.

Sample Metadata Fields

Specimen part, Cell line, Treatment

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accession-icon GSE39355
Expression profiling of mouse primary prostate luminal cells from WT and T-ETV1 mice, which contains human ETV1 cDNA under the endogenous Tmprss2 promoter.
  • organism-icon Mus musculus
  • sample-icon 7 Downloadable Samples
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Description

Chromosomal rearrangements involving ETS factors, ERG and ETV1, occur frequently in prostate cancer. We here examine mouse prostate cells from WT mice with s with T-ETV1 mice, which contains express the truncated human ETV1 under the endogenous Tmprss2 promoter. ETV1 expression can be tracked by GFP expression.

Publication Title

ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients.

Sample Metadata Fields

Specimen part

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accession-icon GSE25140
Prostate specific Pten deletion, Pten-Smad4 deletion, and Pten-p53 deletion
  • organism-icon Mus musculus
  • sample-icon 15 Downloadable Samples
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Description

We used microarrays to detail the global gene expression and identified differentially expressed gene list between wild-type anterior prostates and Ptenpc-/- anterior prostates, Ptenpc-/-Smad4pc-/- and Ptenpc-/- anterior prostates, Ptenpc-/-p53pc-/- and Ptenpc-/- anterior prostates at 15 weeks of age.

Publication Title

SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression.

Sample Metadata Fields

Age, Specimen part

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accession-icon GSE56534
Infection of macrophages by Toxoplasma Progeny from a Type II x Type III cross
  • organism-icon Mus musculus
  • sample-icon 32 Downloadable Samples
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Description

Infection of RAW264.7 cells for 24 hours with 32 Toxoplasma Progeny from a Type II x Type III cross

Publication Title

GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE24437
Persistence of effector memory Th1 cells is regulated by the homeobox only protein Group1 Hopx-/-, Group2 Hopx+/-, Group3 Hopx+/+
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
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Description

Hopx appears to be needed for persistence of Th1 effector memory cells. IFN-gamma-producing Th cells are significantly reduced in Hopx-deficient mice compared to Hopx-expressing littermates and Hopx-deficient Th1 cells show a defective persistence upon adoptive transfer. Moreover, Hopx protects Th1 cells from Fas-mediated cell death in vitro. To further dissect the role of Hopx and to identify target genes of Hopx, we have performed transcriptome analysis to compare gene expression in Hopx-deficient versus Hopx-competent Th1 cells. In agreement with the role of Hopx in supporting survival of Th1 effector memory cells, anti-apoptotic cells were up-regulated and pro-apoptotic genes were down-regulated in Hopx-competent compared to Hopx-deficient Th1 cells.

Publication Title

Persistence of effector memory Th1 cells is regulated by Hopx.

Sample Metadata Fields

Sex, Specimen part

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