Description

The tumor stroma is believed to contribute to some of the most malignant characteristics of epithelial tumors. However, signaling between stromal and tumor cells is complex and remains poorly understood. Here we show that genetic inactivation of Pten in stromal fibroblasts of mouse mammary glands accelerated the initiation, progression and malignant transformation of mammary epithelial tumors.

Publication Title

Pten in stromal fibroblasts suppresses mammary epithelial tumours.

Sample Metadata Fields

Age, Specimen part