publication_authors:Rozman B Results - refine.bio

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Microarray (33)

Platform

Affymetrix Mouse Genome 430 2.0 Array (mouse4302) (33)

Includes Publication

GSE45234

TLR4 senses oxidative stress mediated by partially oxidized microvesicles.

Mus musculus
11 Downloadable Samples

Description

Oxidative stress is a hallmark of inflammation in infection or sterile tissue injury. We show that partially oxidized phospholipids of microvesicles (MVs) from plasma of patients with rheumatoid arthritis or cells exposed to oxidative stress induce activation of TLR4. MVs from healthy donors or reconstituted synthetic MVs can be converted to TLR4 agonists by limited oxidation, while prolonged oxidation abrogates the activity. Activation by MVs mimics the mechanism of TLR4 activation by LPS. However, LPS and MVs induce significantly different transcriptional response profile in mouse BMDMs with a strong inflammation-resolving component induced by the endogenous signals. MVs thus represent a ubiquitous endogenous danger signal released under the oxidative stress, which underlies the pervasive role of TLR4 signaling in inflammation.

Publication Title

Toll-like receptor 4 senses oxidative stress mediated by the oxidation of phospholipids in extracellular vesicles.

Sample Metadata Fields

Sex

GSE48383

ChIp-Chip using RNAP II, CREB C/EBPb and cJun antibody in undifferentiated or differentiated keratinocytes

Mus musculus
10 Downloadable Samples

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Combinatorial recruitment of CREB, C/EBPβ and c-Jun determines activation of promoters upon keratinocyte differentiation.

Sample Metadata Fields

Specimen part, Treatment

GSE48382

ChIp-Chip using RNAP II, CREB C/EBPb and cJun antibody in undifferentiated or differentiated keratinocytes (expression)

Mus musculus
10 Downloadable Samples

Description

Combinatorial recruitment of CREB, C/EBPb and Jun determines activation of promoters upon keratinocyte differentiation

Publication Title

Combinatorial recruitment of CREB, C/EBPβ and c-Jun determines activation of promoters upon keratinocyte differentiation.

Sample Metadata Fields

Specimen part, Treatment

GSE113968

The induction and transcriptional regulation of the co-inhibitory gene module in T cells by IL-27

Mus musculus
12 Downloadable Samples

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Induction and transcriptional regulation of the co-inhibitory gene module in T cells.

Sample Metadata Fields

Specimen part

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