Bisphenol A (BPA), an endocrine-disrupting chemical (EDC), is a well-known, ubiquitous estrogenic chemical. To investigate the effects of fetal exposure to low-dose BPA on the development of the prostate, we first examined the alterations of in situ sex steroid hormonal environment in the mouse urogenital sinus (UGS).
Endocrine disrupter bisphenol A increases in situ estrogen production in the mouse urogenital sinus.
Specimen part
View SamplesIt has been reported that repeated intra-tracheal instillation of S. chartarum spores induced significant pulmonary arterial remodeling in mice, which resulted in pathological changes like human pulmonary arterial hypertension (PAH) and elevation right ventricle systolic pressure.
Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs.
Sex, Specimen part, Disease, Disease stage
View SamplesOur previous investigation indicated that high-virulence C. gattii (C. gattii TIMM 4097) tend to reside in the alveoli, whereas low-virulence C. gattii (C. gattii TIMM 4903) tend to be washed out from the alveoli and move into the central side of the respiratory system. To test this hypothesis, we performed microarray assay.
How histopathology can contribute to an understanding of defense mechanisms against cryptococci.
Sex, Specimen part
View SamplesPerilipin A (PeriA) exclusively locates on adipocyte lipid droplets and is essential for lipid storage and lipolysis. Adipocyte specific overexpression of PeriA caused resistance to diet-induced obesity and resulted in improved insulin sensitivity. In order to better understand the biological basis for this observed phenotype we performed DNA microarray analysis on white adipose tissue (WAT) from PeriA transgenic (Tg) and control wildtype (WT) mice.
Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype.
Sex, Specimen part
View SamplesGoal of experiment: Identify genes down-regulated between pre- and post-natal stages in mouse dental papillae.
Down-regulated genes in mouse dental papillae and pulp.
No sample metadata fields
View SamplesGene expression of Ethanol-treated hepatocytes from WT and transglutaminase 2 knockout mice
Role of transglutaminase 2 in liver injury via cross-linking and silencing of transcription factor Sp1.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Profiling gene expression during the differentiation and development of the murine embryonic gonad.
No sample metadata fields
View SamplesTime course of gene expression in the murine embryonic ovary from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc)
Profiling gene expression during the differentiation and development of the murine embryonic gonad.
No sample metadata fields
View SamplesTime course of gene expression in the murine embryonic testis from the time of the indifferent gonad (11.5dpc) to birth (18.5dpc)
Profiling gene expression during the differentiation and development of the murine embryonic gonad.
No sample metadata fields
View SamplesThis SuperSeries is composed of the SubSeries listed below.
Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.
Specimen part
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