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accession-icon GSE17840
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria
  • organism-icon Mus musculus
  • sample-icon 7 Downloadable Samples
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Description

Epithelial Hedgehog (Hh) ligands regulate several aspects of fetal intestinal organogenesis and emerging data implicate the Hh pathway in inflammatory signaling in adult colon. We investigated the effects of chronic Hh inhibition in vivo and profiled molecular pathways acutely modulated by Hh signaling in the intestinal mesenchyme.

Publication Title

Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria.

Sample Metadata Fields

Specimen part

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accession-icon GSE60639
Transcriptome_Methylome_Sirt1KOESC
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
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Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE60500
Genomewide gene expression analysis of murine Sirt1 wild-type or knock-out embryonic stem cells (ESCs)
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
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Description

Stem-cells and transformed cancer cells specifically express a polycomb repressive complex subtype, PRC4 which characteristically contains Sirt1 (Sirtuin-1), a NAD+ dependent class III histone deacetylase (HDAC) and Eed2 isoform as specific members. Analyzing the transcriptiome and methylome analysis of Sirt1 deficient murine ESCs (Sirt1-/- ESC), we demonstrate that these cells repressed specifically on some genomic imprinted and germ-line related genes.

Publication Title

Sirt1 Regulates DNA Methylation and Differentiation Potential of Embryonic Stem Cells by Antagonizing Dnmt3l.

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE16195
Expression profiling of joint tissue from C3H and interval specific congenic mouse lines post- B. burgdorferi infection
  • organism-icon Mus musculus
  • sample-icon 10 Downloadable Samples
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Description

Gene expression profile of joint tissue from C3H and interval specific congenic mouse lines (ISCL) following infection with Borrelia burgdorferi

Publication Title

Interval-specific congenic lines reveal quantitative trait Loci with penetrant lyme arthritis phenotypes on chromosomes 5, 11, and 12.

Sample Metadata Fields

Specimen part

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accession-icon GSE33660
Direct Recruitment of Polycomb Repressive Complex 1 (PRC1) to Chromatin by Core Binding Transcription Factors
  • organism-icon Mus musculus
  • sample-icon 9 Downloadable Samples
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Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.

Sample Metadata Fields

Specimen part, Cell line

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