Description

In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the -secretase ADAM10 prevented amyloid plaque formation and alleviated cognitive deficits. Furthermore, there was a positive influence of ADAM10 over-expression on neurotransmitter-specific formation of synapses and on synaptic plasticity.

Publication Title

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice.

Sample Metadata Fields

Sex, Age