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accession-icon GSE10908
Differential gene expression in ADAM10 over-expressing transgenic mice
  • organism-icon Mus musculus
  • sample-icon 27 Downloadable Samples
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Description

In a transgenic mouse model of Alzheimer disease (AD), cleavage of the amyloid precursor protein (APP) by the -secretase ADAM10 prevented amyloid plaque formation and alleviated cognitive deficits. Furthermore, there was a positive influence of ADAM10 over-expression on neurotransmitter-specific formation of synapses and on synaptic plasticity.

Publication Title

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice.

Sample Metadata Fields

Sex, Age

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accession-icon GSE6770
Gene Expression Data in HDAC2 KO Myocardium
  • organism-icon Mus musculus
  • sample-icon 4 Downloadable Samples
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Description

We used microarrays to detail the global programme of gene expression underlying cardiac development by HDAC2 and identified distinct classes of up-regulated and down-regulated genes during this process.

Publication Title

Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity.

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